The discovery comes from the USA, by researchers at the Boston Children's Hospital and Weill Cornell Medical College is the first time this has happened. This is a new hope for all people with leukemia or other blood disorders who do not find a compatible donor
Twenty years ago the first attempts and today-informs the prestigious scientific journal Nature-finally managed to achieve hematopoietic stem cells in the laboratory, namely those stem cells from which originate all blood cells: red blood cells, platelets and white. This is a milestone, because it opens a window of hope for people with leukemia or other blood disorders, which would need a bone marrow transplant but fail to find the donor; in the near future we could get to create unlimited reserves healthy cells.
Two teams of scholars who, albeit through separate searches, have reached the same result.
A group, led by George Daley, of Boston Children's Hospital, Massachusetts, started with human pluripotent stem cells, or those who have the ability to generate all kinds of cells of our body: after being reprogrammed to make became endothelial cells of blood vessels, were treated with a special sauce of proteins, as defined by Daley and then the cells were transplanted into the bone marrow of mice; in 20% of the rodents have given rise to different types of blood cells.
Another team, headed by Shahin Rafii of Weill Cornell Medical College, New York scored hematopoietic stem cells by vascular endothelial cells, namely those which line the blood vessels. After having taken from mice, researchers have engineered to bring them back to a primordial stage; then exposed them to a particular mix of proteins and kept in incubation for a little over a month, after which they replanted in animals. Once returned, the cells continued to regenerate and produce various types of blood cells, without causing any immune reaction.
Both searches need for further study, since the cells created in the laboratory are working but have a molecular structure still fairly different from that of native cells; but, in these circumstances, scholars are confident.
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